356 – AMA #73: Preserving brain health, optimizing exercise programming, improving body composition, and more (7/14/2025)
Navigating bone health: early life influences and advanced strategies for improvement and injury prevention (#214 rebroadcast) (7/7/2025)
#355 – Skincare strategies, the science of facial aging, and cosmetic-intervention guidance | Tanuj Nakra, M.D. & Suzan Obagi, M.D. (6/30/2025)
#354 – What the dying can teach us about living well: lessons on life and reflections on mortality | BJ Miller, M.D. and Bridget Sumser, L.C.S.W. (6/23/2025)
#353 – AMA #72: Fasting: benefits for body composition and disease prevention, potential risks, and Peter’s updated practical framework (6/16/2025)
#352 ‒ Female fertility: optimizing reproductive health, diagnosing and treating infertility and PCOS, and understanding the IVF process | Paula Amato, M.D. (6/9/2025)
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D. (6/2/2025)
#350 ‒ Injury prevention, recovery, and performance optimization for every decade | Kyler Brown, D.C. (5/25/2025)
#349 – AMA #71: Building strength and muscle mass: how to optimize training, nutrition, and more for longevity (5/19/2025)
#348 ‒ Women’s sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D. (5/12/2025)
#347 – Peter’s takeaways on mastering sleep, dealing with chronic pain, developing breakthrough cancer drugs, transforming healthcare with AI, advancing radiation therapy, and healing trauma | Quarterly Podcast Summary #5 (5/5/2025)
#346 ‒ Scaling biotech and improving global health: lessons from an extraordinary career in medicine | Susan Desmond-Hellmann, M.D., M.P.H. (4/28/2025)
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D. (4/21/2025)
#344 – AMA #70: Nicotine: impact on cognitive function, performance, and mood, health risks, delivery modalities, and smoking cessation strategies (4/14/2025)
#343 – The evolving role of radiation: advancements in cancer treatment, emerging low-dose treatments for arthritis, tendonitis, and injuries, and addressing misconceptions | Sanjay Mehta, M.D. (4/7/2025)
#342 ‒ Aging well: Peter shares strategies for improving longevity with residents at a senior living center (3/31/2025)
#341 – Overcoming insomnia: improving sleep hygiene and treating disordered sleep with cognitive behavioral therapy for insomnia | Ashley Mason, Ph.D. (3/24/2025)
#340 – AMA #69: Scrutinizing supplements: creatine, fish oil, vitamin D, and more—a framework for understanding effectiveness, quality, and individual need (3/17/2025)
#339 – Unpacking trauma: How early wounds shape behavior and the path toward healing | Jeff English (3/10/2025)
#338 ‒ Peter’s takeaways on aerobic exercise and VO2 max, insulin resistance, rising healthcare costs, treating children with autism and ADHD, and strength training | Quarterly Podcast Summary #4 (3/3/2025)
#337 – Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment | Ralph DeFronzo, M.D. (2/24/2025)
#336 – AMA #68: Fasting, well-balanced diets, alcohol, exercise for busy people, wearables, emotional health, assessing cardiovascular health, and more (2/17/2025)
#335 ‒ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D. (2/9/2025)
#334 – Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more | Tom Dayspring, M.D. (2/3/2025)
#333 ‒ Longevity roundtable — the science of aging, geroprotective molecules, lifestyle interventions, challenges in research, and more | Steven Austad, Ph.D., Matt Kaeberlein, Ph.D., Richard Miller, M.D., Ph.D. (1/27/2025)
#332 – AMA #67: Microplastics, PFAS, and phthalates: understanding health risks and a framework for minimizing exposure and mitigating risk (1/20/2025)
#331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2) (1/13/2025)
#330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D. (1/6/2025)
#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more (12/16/2024)
328 – AMA #66: Optimizing nutrition for health and longevity: myth of a “best” diet, complexities of nutrition science, and practical steps for building a sustainable diet (12/9/2024)
#327 – Choices, costs, and challenges in US healthcare: insurance intricacies, drug pricing, economic impacts, and potential reforms | Saum Sutaria, M.D. (12/2/2024)
#326 – AMA #65: Red light therapy: promising applications, mixed evidence, and impact on health and aging (11/18/2024)
#325 ‒ Peter’s key takeaways on bone health, calorie restriction and energy balance, dopamine and addiction, gene editing, and testosterone therapy safety with a prostate cancer diagnosis | Quarterly Podcast Summary #3 (11/11/2024)
#324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D. (11/4/2024)
#323 – CRISPR and the future of gene editing: scientific advances, genetic therapies, disease treatment potential, and ethical considerations | Feng Zhang, Ph.D. (10/28/2024)
#322 – Bone health for life: building strong bones, preventing age-related loss, and reversing osteoporosis with evidence-based exercise | Belinda Beck, Ph.D. (10/21/2024)
#321 – Dopamine and addiction: navigating pleasure, pain, and the path to recovery | Anna Lembke, M.D. (10/14/2024)
#320 – AMA 64: New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro) – efficacy, benefits, risks, and considerations in the rapidly evolving weight-loss drug landscape (10/7/2024)
#319 ‒ Peter’s key takeaways on liver health, heart rate variability, AI in medicine, klotho, and lactate metabolism | Quarterly Podcast Summary #2 (9/30/2024)
#318 ‒ Cycling phenom and Tour de France champion Tadej Pogačar reveals his training strategies, on-bike nutrition, and future aspirations (9/23/2024)
#317 ‒ Reforming medicine: uncovering blind spots, challenging the norm, and embracing innovation | Marty Makary, M.D., M.P.H. (9/16/2024)
#316 – AMA #63: A guide for hair loss: causes, treatments, transplants, and sex-specific considerations (9/9/2024)
#315 ‒ Life after near-death: a new perspective on living, dying, and the afterlife | Sebastian Junger (8/26/2024)
#314 ‒ Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards | David Allison, Ph.D. (8/19/2024)
#313 – AMA #62: Protein’s impact on appetite and weight management, and uric acid’s link to disease and how to manage levels (8/12/2024)
#312 – A masterclass in lactate: Its critical role as metabolic fuel, implications for diseases, and therapeutic potential from cancer to brain health and beyond | George A. Brooks, Ph.D. (8/5/2024)
#311 ‒ Longevity 101: a foundational guide to Peter’s frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more (7/29/2024)
#310 – The relationship between testosterone and prostate cancer, testosterone replacement therapy, and tools for predicting cancer aggressiveness and guiding therapy | Ted Schaeffer, M.D., Ph.D. (7/22/2024)
#309 ‒ AI in medicine: its potential to revolutionize disease prediction, diagnosis, and outcomes, causes for concern in medicine and beyond, and more | Isaac Kohane, M.D., Ph.D. (7/15/2024)
#308 – AMA #61: Sun exposure, sunscreen, and skin health: relationship between sun exposure and skin cancer, vitamin D production, and photoaging, how to choose a sunscreen, and more (7/1/2024)
#307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D. (6/24/2024)
#306 – AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more (6/17/2024)
#305 ‒ Heart rate variability: how to measure, interpret, and utilize HRV for training and health optimization | Joel Jamieson (6/10/2024)
#304 – NEW: Introducing quarterly podcast summaries – Peter shares his biggest takeaways on muscle protein synthesis, VO2 max, toe strength, gut health, and more (6/3/2024)
#303 – A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer’s disease | Dena Dubal, M.D., Ph.D. (5/27/2024)
#302 – Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage MAFLD and liver disease | Julia Wattacheril, M.D., M.P.H. (5/20/2024)
#301 – AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it (5/13/2024)
#300 – Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise? (5/6/2024)
Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death (4/29/2024)
#299 ‒ Optimizing muscle protein synthesis: the crucial impact of protein quality and quantity, and the key role of resistance training | Luc van Loon, Ph.D. (4/22/2024)
#298 ‒ The impact of emotional health on longevity, self-audit strategies, improving well-being, and more | Paul Conti, M.D. (4/15/2024)
#297 – AMA #58: Iron: its role in health, testing methods, and strategies for preventing and managing iron deficiency (4/8/2024)
#296 ‒ Foot health: preventing and treating common injuries, enhancing strength and mobility, picking footwear, and more | Courtney Conley, D.C. (4/1/2024)
#295 ‒ Roadway death and injury: why everyone should care and what you can do to reduce risk | Mark Rosekind, Ph.D. (3/25/2024)
#294 ‒ Peak athletic performance: How to measure it and how to train for it from the coach of the most elite athletes on earth | Olav Aleksander Bu (3/18/2024)
#293 – AMA #57: High-intensity interval training: benefits, risks, protocols, and impact on longevity (3/11/2024)
#292 ‒ Rucking: benefits, gear, FAQs, and the journey from Special Forces to founding GORUCK | Jason McCarthy (3/4/2024)
#291 ‒ The role of testosterone in males and females, performance-enhancing drugs, sustainable fat loss, supplements, and more | Derek, More Plates More Dates Pt.2 (2/26/2024)
#290 ‒ Liquid biopsies for early cancer detection, the role of epigenetics in aging, and the future of aging research | Alex Aravanis, M.D., Ph.D. (2/19/2024)
#289 – AMA #56: Cancer screening: pros and cons, screening options, interpreting results, and more (2/12/2024)
#288 ‒ The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green (2/5/2024)
#287 ‒ Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D. (1/29/2024)
#286 ‒ Journal club with Andrew Huberman: the impact of light exposure on mental health and an immunotherapy breakthrough for cancer treatment (1/22/2024)
#285 – AMA #55: Exercise: longevity-focused training, goal setting, improving deficiencies, managing emotional stress, and more (1/15/2024)
#284 ‒ Overcoming addictive behaviors, elevating wellbeing, thriving in an era of excess, and the scarcity loop | Michael Easter, M.A. (1/8/2024)
#283 ‒ Gut health & the microbiome: improving and maintaining the microbiome, probiotics, prebiotics, innovative treatments, and more | Colleen Cutcliffe, Ph.D. (12/18/2023)
#282 – AMA #54: Magnesium: risks of deficiency, how to correct it, supplement options, potential cognitive and sleep benefits, and more (12/11/2023)
#281 ‒ Longevity drugs, aging biomarkers, and updated findings from the Interventions Testing Program (ITP) | Rich Miller, M.D., Ph.D. (12/4/2023)
#280 ‒ Cultivating happiness, emotional self-management, and more | Arthur Brooks Ph.D. (11/27/2023)
#279 – AMA #53: Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins (11/13/2023)
#278 ‒ Breast cancer: how to catch, treat, and survive breast cancer | Harold Burstein, M.D., Ph.D. (11/6/2023)
#277 ‒ Food allergies: causes, prevention, and treatment with immunotherapy | Kari Nadeau, M.D., Ph.D. (10/30/2023)
#276 ‒ Special episode: Peter answers questions on longevity, supplements, protein, fasting, apoB, statins, and more (10/23/2023)
#275 – AMA #52: Hormone replacement therapy: practical applications and the role of compounding pharmacies (10/16/2023)
#274 – Performance-enhancing drugs and hormones: risks, rewards, and broader implications for the public | Derek: More Plates, More Dates (10/9/2023)
#273 ‒ Prostate health: common problems, cancer prevention, screening, treatment, and more | Ted Schaeffer, M.D., Ph.D. (10/2/2023)
#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D. (9/25/2023)
#271 – AMA #51: Understanding and improving your metabolic health (9/18/2023)
#270 ‒ Journal club with Andrew Huberman: metformin as a geroprotective drug, the power of belief, and how to read scientific papers (9/11/2023)
#269 – Good vs. bad science: how to read and understand scientific studies (9/4/2023)
#268 ‒ Genetics: testing, therapy, editing, association with disease risk, autism, and more | Wendy Chung, M.D., Ph.D. (8/28/2023)
#267 ‒ The latest in cancer therapeutics, diagnostics, and early detection | Keith Flaherty, M.D. (8/21/2023)
#266 – AMA #50: Genetics: how they impact disease risk, what you can do about it, testing, and more (8/14/2023)
#265 – Time, productivity, and purpose: insights from Four Thousand Weeks | Oliver Burkeman (8/7/2023)
#264 ‒ Hip, knee, ankle, and foot: diagnosis, treatment, and surgery of the lower extremities | Adam Cohen, M.D. (7/31/2023)
#263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D. (7/24/2023)
#262 – AMA #49: Heart rate recovery, strength training, rucking, kidney function, and brain health (7/17/2023)
#261 ‒ Training for The Centenarian Decathlon: zone 2, VO2 max, stability, and strength | Peter Attia, M.D. (7/10/2023)
#260 ‒ Men’s Sexual Health: why it matters, what can go wrong, and how to fix it | Mohit Khera, M.D., M.B.A., M.P.H. (6/26/2023)
#259 – Women’s sexual health: Why it matters, what can go wrong, and how to fix it | Sharon Parish, M.D. (6/19/2023)
#258 – AMA #48: Blood pressure—how to measure, manage, and treat high blood pressure (6/12/2023)
#257 ‒ Cognitive decline, neurodegeneration, and head injuries: mitigation and prevention strategies, supplements, and more | Tommy Wood, M.D., Ph.D. (6/5/2023)
#256 ‒ The endocrine system: exploring thyroid, adrenal, and sex hormones | Peter Attia, M.D. (5/29/2023)
#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D. (5/22/2023)
#254 – AMA #47: Cold therapy: pros, cons, and its impact on longevity (5/15/2023)
#253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | JoAnn Manson, M.D. (5/8/2023)
#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D. (5/1/2023)
#251 – AMA #46: Optimizing brain health: Alzheimer’s disease risk factors, APOE, prevention strategies, and more (4/17/2023)
#250 ‒ Training principles for longevity | Andy Galpin, Ph.D. (PART II) (4/10/2023)
#249 ‒ How the brain works, Andrew’s fascinating backstory, improving scientific literacy, and more | Andrew Huberman, Ph.D. (4/3/2023)
#248 ‒ OUTLIVE book: A behind-the-scenes look into the writing of this book, motivation, main themes, and more (3/28/2023)
#247 ‒ Preventing cardiovascular disease: the latest in diagnostic imaging, blood pressure, metabolic health, and more | Ethan Weiss, M.D. (3/20/2023)
#246 – AMA #45: Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent (3/13/2023)
#245 ‒ Overcoming trauma, finding inner peace, and living a meaningful and fulfilling life | Lewis Howes (3/6/2023)
#244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee (2/27/2023)
#243 ‒ The fentanyl crisis and why everyone should be paying attention | Anthony Hipolito (2/20/2023)
#242 – AMA #44: Peter’s historical changes in body composition with his evolving dietary, fasting, and training protocols (2/13/2023)
#241 ‒ Living intentionally, valuing time, prioritizing relationships, and more keys to a rich life | Ric Elias (Part 2) (2/6/2023)
#240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D. (1/30/2023)
#239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I) (1/23/2023)
#238 – AMA #43: Understanding apoB, LDL-C, Lp(a), and insulin as risk factors for cardiovascular disease (1/16/2023)
#237 ‒ Optimizing life for maximum fulfillment | Bill Perkins (1/9/2023)
#235 ‒ Training principles for mass and strength, changing views on nutrition, creatine supplementation, and more | Layne Norton, Ph.D. (12/19/2022)
#234 ‒ Chris Hemsworth on Limitless, longevity, and happiness (12/12/2022)
#233 – AMA #42: Optimizing sleep – bedtime routine, molecule regimen, sleep trackers, sauna, & more (12/5/2022)
#232 ‒ Shoulder, elbow, wrist, and hand: diagnosis, treatment, and surgery of the upper extremities | Alton Barron, M.D. (11/28/2022)
#231 – AMA #41: Medicine 3.0, developments in the field of aging, healthy habits in times of stress, and more (11/14/2022)
#230 ‒ Cardiovascular disease in women: prevention, risk factors, lipids, and more | Erin Michos, M.D. (11/7/2022)
#229 ‒ Understanding cardiovascular disease risk, cholesterol, and apoB (10/31/2022)
#228 ‒ Improving body composition, female-specific training principles, and overcoming an eating disorder | Holly Baxter, APD (10/24/2022)
#227 – AMA #40: Body composition, protein, time-restricted feeding, fasting, DEXA scans, and more (10/17/2022)
#226 ‒ The science of happiness | Arthur Brooks, Ph.D. (10/10/2022)
#225 ‒ The comfort crisis, doing hard things, rucking, and more | Michael Easter, MA (10/3/2022)
#224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D. (9/26/2022)
#223 – AMA #39: The Centenarian Decathlon, zone 2, VO2 max, and more (9/19/2022)
#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D. (9/12/2022)
#221 ‒ Understanding sleep and how to improve it (9/5/2022)
#220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D. (8/29/2022)
#219 ‒ Dialectical behavior therapy (DBT): skills for overcoming depression, emotional dysregulation, and more | Shireen Rizvi, Ph.D., ABPP (8/22/2022)
#218 – AMA #38: Can you exercise too much? (8/15/2022)
#217 ‒ Exercise, VO2 max, and longevity | Mike Joyner, M.D. (8/8/2022)
#216 – Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D. (8/1/2022)
#215 – The gut-brain connection | Michael Gershon, M.D. (7/25/2022)
#214 – AMA #37: Bone health—everything you need to know (7/18/2022)
#213 ‒ Liquid biopsies and cancer detection | Max Diehn, M.D. Ph.D. (7/11/2022)
#212 – The neuroscience of obesity | Stephan Guyenet, Ph.D. (6/27/2022)
#211 – AMA #36: Fruits & vegetables—everything you need to know (6/20/2022)
#210 – Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D. (6/13/2022)
#209 ‒ Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H. (6/6/2022)
#208 – Tragedy, grief, healing, and finding happiness | Kelsey Chittick (5/23/2022)
#207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin (5/16/2022)
#206 – Exercising for longevity: strength, stability, zone 2, zone 5, and more (5/9/2022)
#205 – Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2) (5/2/2022)
#204 – Centenarians, metformin, and longevity | Nir Barzilai, M.D. (4/25/2022)
#203 – AMA #34: What Causes Heart Disease? (4/18/2022)
#202 – Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes (4/11/2022)
#201 – Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2) (3/28/2022)
#200 – AMA #33: Hydration—electrolytes, supplements, sports drinks, performance effects, and more (3/21/2022)
#199 – Running, overcoming challenges, and finding success | Ryan Hall (3/14/2022)
#198 – Eye health—everything you need to know | Steven Dell, M.D. (3/7/2022)
#197 – The science of obesity & how to improve nutritional epidemiology | David Allison, Ph.D. (2/28/2022)
#196 – AMA #32: Exercise, squats, deadlifts, BFR, and TRT (2/21/2022)
#195 – Freedom, PTSD, war, and life through an evolutionary lens | Sebastian Junger (2/14/2022)
#194 – How fructose drives metabolic disease | Rick Johnson, M.D. (2/7/2022)
#193 – AMA #31: Heart rate variability (HRV), alcohol, sleep, and more (1/31/2022)
#192 – COVID Part 2: Masks, long COVID, boosters, mandates, treatments, and more (1/24/2022)
#191 – Revolutionizing our understanding of mental illness with optogenetics | Karl Deisseroth M.D., Ph.D. (1/17/2022)
#190 – Paul Conti, M.D.: How to heal from trauma and break the cycle of shame (1/10/2022)
#189 – COVID Part 1: Current state of affairs, Omicron, and a search for the end game (1/3/2022)
#188 – AMA #30: How to Read and Understand Scientific Studies (12/20/2021)
#187 – Sam Apple: The Warburg Effect—Otto Warburg’s cancer metabolism theory (12/13/2021)
#186 – Patrick Radden Keefe: The opioid crisis—origin, guilty parties, and the difficult path forward (12/6/2021)
#185 – Allan Sniderman, M.D.: Cardiovascular disease and why we should change the way we assess risk (11/29/2021)
#184 – AMA #29: GLP-1 Agonists – The Future of Treating Obesity? (11/15/2021)
#183 – James Clear: Building & Changing Habits (11/8/2021)
#182 – David Nutt: Psychedelics & Recreational Drugs (11/1/2021)
#181 – Robert Gatenby, M.D.: Viewing cancer through an evolutionary lens and why this offers a radically different approach to treatment (10/25/2021)
#180 – AMA #28: All things testosterone and testosterone replacement therapy (10/18/2021)
#179 – Jeremy Loenneke, Ph.D.: The science of blood flow restriction—benefits, uses, and what it teaches us about the relationship between muscle size and strength (10/11/2021)
#178 – Lance Armstrong: The rise, fall, and growth of a cycling legend (10/4/2021)
#177 – Steven Rosenberg, M.D., Ph.D.: The development of cancer immunotherapy and its promise for treating advanced cancers (9/27/2021)
#176 – AMA #27: The importance of muscle mass, strength, and cardiorespiratory fitness for longevity (9/20/2021)
#175 – Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process (9/13/2021)
#174 – Lawrence Wright: The 20th anniversary of the 9/11 attacks: reflections on how they happened, and lessons learned and not learned (9/6/2021)
#173 – AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions (8/23/2021)
#172 – Esther Perel: The effects of trauma, the role of narratives in shaping our worldview, and why we need to accept uncomfortable emotions (8/16/2021)
#171 – Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules (8/9/2021)
#170 – AMA #25: Navigating the complexities and nuances of cancer screening (7/26/2021)
#169 – Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation (7/19/2021)
#168 – Hugh Jackman: Reflections on acting, identity, personal transformation, and the significance of being Wolverine (7/12/2021)
#167 – Gary Taubes: Bad science and challenging the conventional wisdom of obesity (6/28/2021)
#166 – Patricia Corby, D.D.S.: Importance of oral health, best hygiene practices, and the relationship between poor oral health and systemic disease (6/21/2021)
#165 – AMA #24: Deep dive into blood glucose: why it matters, important metrics to track, and superior insights from a CGM (6/14/2021)
#164 – Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer’s disease, and what we can all learn from patients with dementia (6/7/2021)
#163 – Layne Norton, Ph.D.: Building muscle, losing fat, and the importance of resistance training (5/24/2021)
#162 – Sarah Hallberg, D.O., M.S.: Challenging the status quo of treating metabolic disease, and a personal journey through a grim cancer diagnosis (5/17/2021)
#161 – AMA #23: All Things Nicotine: deep dive into its cognitive and physical benefits, risks, and mechanisms of action (5/10/2021)
#160 – Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variants (5/3/2021)
#159 – Peter Hotez, M.D., Ph.D.: Evolution of the anti-vaccine movement, the causes of autism, and COVID-19 vaccine state of affairs (4/26/2021)
#158 – Brian Deer: A tale of scientific fraud—exposing Andrew Wakefield and the origin of the belief that vaccines cause autism (4/19/2021)
#157 – AMA #22: Losing fat and gaining fat: the lessons of fat flux (4/12/2021)
#156 – Jake Muise: Humanely harvesting axis deer while alleviating its impact on Hawaii’s vulnerable ecosystems (4/5/2021)
#155 – Chris Sonnenday, M.D.: The history, challenges, and gift of organ transplantation (3/29/2021)
#154 – Steve Levitt, Ph.D.: A rogue economist’s view on climate change, mental health, the ethics of experiments, and more (3/22/2021)
#153 – AMA #21: Deep dive into olive oil, high-intensity exercise, book update, and more (3/15/2021)
#152 – Michael Rintala, D.C.: Principles of Dynamic Neuromuscular Stabilization (DNS) (3/8/2021)
#151 – Alex Hutchinson, Ph.D.: Translating the science of endurance and extreme human performance (3/1/2021)
#150 – Senator Bill Frist, M.D.: A modern Renaissance man’s journey through science, politics, and business (2/22/2021)
#149 – AMA #20: Simplifying the complexities of insulin resistance: how it’s measured, how it manifests in the muscle and liver, and what we can do about it (2/15/2021)
#148 – Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program (2/8/2021)
#147 – Hussein Yassine, M.D.: Deep dive into the “Alzheimer’s gene” (APOE), brain health, and omega-3s (2/1/2021)
#146 – Guy Winch, Ph.D.: Emotional first aid and how to treat psychological injuries (1/25/2021)
#145 – AMA #19: Deep dive on Zone 2 training, magnesium supplementation, and how to engage with your doctor (1/18/2021)
#144 – Phil Maffetone: Optimizing health and performance through maximal aerobic function (1/11/2021)
#143 – John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it (1/4/2021)
#142 – Robert Abbott: The Bobby Knight story—a cautionary tale of unchecked anger, ego, and winning at all costs (12/21/2020)
#141 – AMA #18: Deep dive: sugar and sugar substitutes (12/14/2020)
#140 – Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications (12/7/2020)
#139 – Kristin Neff, Ph.D.: The Power of Self-Compassion (11/30/2020)
#138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives (11/23/2020)
#137 – Paul Offit, M.D.: An expert perspective on COVID-19 vaccines (11/16/2020)
#136 – AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico (11/9/2020)
#135 – BJ Miller, M.D.: How understanding death leads to a better life (11/2/2020)
#134 – James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise (10/26/2020)
#133 – Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy (10/19/2020)
#132 – AMA #16: Exploring hot and cold therapy (10/12/2020)
#130 – Carol Tavris, Ph.D. & Elliot Aronson, Ph.D.: Recognizing and overcoming cognitive dissonance (9/28/2020)
#129 – Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology (9/21/2020)
#128 – Irene Davis, Ph.D.: Evolution of the foot, running injuries, and minimalist shoes (9/14/2020)
#127 – AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more (9/7/2020)
#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book (8/31/2020)
#125 – John Arnold: The most prolific philanthropist you may not have heard of (8/24/2020)
#124 – AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more (8/17/2020)
#123 – Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19 (8/10/2020)
#122 – Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health (8/3/2020)
#121 – Azra Raza, M.D.: Why we’re losing the war on cancer (7/27/2020)
#120 – AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health (7/20/2020)
#119 – Terry Real: Breaking the cycle of shame, anger, and depression (7/13/2020)
#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging (7/6/2020)
#117 – Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19 (6/29/2020)
#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise (6/22/2020)
#115 – David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19 (6/15/2020)
#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies (6/8/2020)
#113: Normative errors — a conversation with my daughter about current events (6/3/2020)
#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it (6/1/2020)
#111 – AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity (5/18/2020)
#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K (5/11/2020)
#109 – John Dudley: The beauty in archery, the love of practice, and a model system for life (5/4/2020)
#108 – AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity (4/21/2020)
#107 – John Barry: 1918 Spanish flu pandemic—historical account, parallels to today, and lessons (4/17/2020)
#106 – Amesh Adalja, M.D.: Comparing COVID-19 to past pandemics, preparing for the future, and reasons for optimism (4/13/2020)
#105 – Paul Conti, M.D.: The psychological toll of a pandemic, and the societal problems it has highlighted (4/10/2020)
#104 – COVID-19 for kids with Olivia Attia (4/8/2020)
#103 – Looking back on the first 99 episodes: Strong Convictions, Loosely Held (4/6/2020)
#102 – Michael Osterholm, Ph.D.: COVID-19—Lessons learned, challenges ahead, and reasons for optimism and concern (3/31/2020)
#101 – Ryan Holiday: Finding stillness amidst chaos (3/27/2020)
#100 – Sam Harris, Ph.D.: COVID-19—Comprehending the crisis and managing our emotions (3/24/2020)
#99 – Peter Hotez, M.D., Ph.D.: Continuing the conversation on COVID-19 (3/20/2020)
#97 – Peter Hotez, M.D., Ph.D.: COVID-19: transmissibility, vaccines, risk reduction, and treatment (3/14/2020)
#96 – David Epstein: How a range of experience leads to better performance in a highly specialized world (3/9/2020)
#95 – Luke Bennett, M.D.: The emotional, cognitive, and physical demands that make Formula 1 a unique and special sport (3/2/2020)
#94 – Mark Hyman, M.D.: The impact of the food system on our health and the environment (2/24/2020)
#93 – AMA with Jason Fried: Work-life balance, avoiding burnout, defining success, company culture, and more (2/17/2020)
#92 – AMA #12: Strategies for longevity (which don’t require a doctor) (2/10/2020)
#91 – Eric Topol, M.D.: Can AI empower physicians and revolutionize patient care? (2/3/2020)
#90 – Ryan Holiday: Stillness, stoicism, and suffering less (1/27/2020)
#89 – AMA #11: All things fasting (1/20/2020)
#87 – Rick Johnson, M.D.: Metabolic Effects of Fructose (1/6/2020)
#86 – Damon Hill: Overcoming loss, achieving success, and finding one’s identity (12/30/2019)
#85 – Iñigo San Millán, Ph.D.: Zone 2 Training and Metabolic Health (12/23/2019)
#84 – AMA #10: Low testosterone, hypothyroidism, building muscle (and preserving it while fasting) (12/16/2019)
#83 – Bill Harris, Ph.D.: Omega-3 fatty acids (12/9/2019)
#82 – Mark Messier: Leadership, personal growth, and performing under pressure (12/2/2019)
#81 – Debra Kimless, M.D. & Steve Goldner, J.D.: Cannabis – the latest science on CBD & THC (11/25/2019)
#80 – Celebrity AMA with Apolo Ohno and Sasha Cohen: Fasting, rapamycin, performance vs. longevity, and more (11/18/2019)
#79 – Ric Elias: Earning the gift of life (11/11/2019)
#78 – Sasha Cohen: The price of achievement, and redefining success (11/4/2019)
#77 – AMA #2 with sleep expert, Matthew Walker, Ph.D.: short sleep mutants, optimal sleep environment, sleep apnea, & rapid fire questions (10/28/2019)
#76 – Kyle Kingsbury: Finding meaning, depression, and psychedelics (10/21/2019)
#75 – David Light: Zantac recall due to cancer concerns – what you need to know (10/14/2019)
#74 – Jason Fried: Optimizing efficiency and work-life balance (10/7/2019)
#73 – AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and more (9/30/2019)
#72 – Dan Harris: 10% happier – meditation, kindness, and compassion (9/23/2019)
#71 – Katherine Eban: Widespread fraud in the generic drug industry (9/16/2019)
#70 – David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD) (9/9/2019)
#69 – Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly (9/2/2019)
#68 – Marty Makary, M.D.: The US healthcare system—why it’s broken, steps to fix it, and how to protect yourself (8/26/2019)
#67 – AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more (8/19/2019)
#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria? (8/12/2019)
#65 – Rick Doblin, Ph.D.: MDMA — the creation, scheduling, toxicity, therapeutic use, and changing public opinion of what is possibly the single most important synthetic molecule ever created by our species (8/5/2019)
#64 – Zol Kryger, M.D.: Navigating the sometimes shady world of plastic surgery—understanding potential complications of common procedures and how to reduce your risk by choosing the right doctor and asking the right questions (7/29/2019)
#63 – AMA #7: Exercise framework, deadlifting, lower back pain, blood pressure, nootropics, CGM, and more (7/22/2019)
#62 – Keith Flaherty, M.D.: Deep dive into cancer— History of oncology, novel approaches to treatment, and the exciting and hopeful future (7/15/2019)
#61 – Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiology (7/8/2019)
The one-year anniversary episode with Olivia Attia: Reflecting on the past year and looking forward to exciting times ahead (7/2/2019)
#60 – Annie Duke, decision strategist: Poker as a model system for life—how to improve decision making, use frameworks for learning, and apply ‘backcasting’ to boost your odds for future success (7/1/2019)
#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness (6/24/2019)
#58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping better, and avoiding things that are disrupting sleep (6/17/2019)
#57 – Rick Rubin, legendary music producer: collaborating with sensitive psyche of greatest living musicians, and his personal story of weight loss and spiritual quest (6/10/2019)
#56 – Jocko Willink, retired Navy SEAL, Part II of II: Sleep, fasting, raising kids, discipline, taking ownership, and the impact of war (6/3/2019)
#55 – Jocko Willink, retired Navy SEAL, Part I of II: objective, strategy & tactics, leadership, protocols, dealing with death, and applying the many lessons learned from war (5/27/2019)
#54 – Kevin Sayer, CEO of Dexcom: Continuous glucose monitors – impact of food, sleep, and stress on glucose, the unmatched power of CGM to drive behavioral change, and the exciting future of CGM (5/20/2019)
#53 – AMA #6: Fasting framework, vitamin supplementation, antioxidants, time management, problem-solving, and more (5/13/2019)
#52 – Ethan Weiss, M.D.: A masterclass in cardiovascular disease and growth hormone – two topics that are surprising interrelated (5/6/2019)
The Ayrton Senna Episode (re-release): Celebrating the greatest driver in Formula 1 history and the cautionary tales of driven individuals (5/1/2019)
#51 – Robert Sapolsky, Ph.D.: The pervasive effect of stress – is it killing you? (4/29/2019)
#50 – AMA #5: calcium scores, Centenarian Decathlon™, exercise, muscle glycogen, keto, and more (4/22/2019)
#49 – Matthew Walker, Ph.D., on sleep – Part III of III: The penetrating effects of poor sleep from metabolism to performance to genetics, and the impact of caffeine, alcohol, THC, and CBD on sleep (4/15/2019)
#48 – Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer, sexual function, and the causes of sleep disruption (and tips to correct it) (4/8/2019)
#47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of poor sleep, Alzheimer’s risk, mental health, memory consolidation, and more (4/1/2019)
#46 – Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease – NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine and more (3/25/2019)
#45 – AMA #4: sleep, jet lag protocol, autophagy, metformin, and more (3/18/2019)
#44 – Jeremy Schaap, ESPN journalist: upsets, doping, triumphs, and the importance of sports (3/11/2019)
#43 – Alan Bauman, M.D.: The science of male and female hair restoration – how to protect, enhance, and restore the appearance and health of the hair and scalp (3/4/2019)
#42 – Avrum Bluming, M.D. and Carol Tavris, Ph.D.: Controversial topic affecting all women—the role of hormone replacement therapy through menopause and beyond—the compelling case for long-term HRT and dispelling the myth that it causes breast cancer (2/25/2019)
#41 – Jake Kushner, M.D.: How to thrive with type 1 diabetes and how everyone can benefit from the valuable insights (2/18/2019)
#40 – Tom Catena, M.D.: The world’s most important doctor – to nearly a million patients – saving countless lives in the war-torn and remote villages of Sudan (2/11/2019)
#39 – Ted Schaeffer, M.D., Ph.D.: How to catch, treat, and survive prostate cancer (2/4/2019)
#38 – Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer’s disease treatment and prevention – is AD actually a vascular and metabolic disease? (1/28/2019)
#37 – Zubin Damania, M.D.: Revolutionizing healthcare one hilariously inspiring video at a time (1/21/2019)
#36 – Eric Chehab, M.D.: Extending healthspan and preserving quality of life (1/14/2019)
#35 – Nir Barzilai, M.D.: How to tame aging (1/7/2019)
#34 – Sam Harris, Ph.D.: The transformative power of mindfulness (12/20/2018)
#33 – Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin (12/17/2018)
#32 – Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing process (12/10/2018)
#31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease (12/3/2018)
#30 – Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease? (11/26/2018)
#29 – Apolo Anton Ohno: 8-time Olympic medalist – extreme training, discipline, pursuing perfection, and responding to adversity (11/19/2018)
#28 – Mark and Chris Bell: steroids, powerlifting, addiction, diet, training, helping others, documentaries, and living your best life (11/12/2018)
#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging (11/5/2018)
#26 – AMA #3: supplements, women’s health, patient care, and more (10/29/2018)
#25 – Scott Harrison: transformation, finding meaning, and taking on the global water crisis (10/22/2018)
#24 – Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more (10/19/2018)
#23 – Tom Dayspring, M.D., FACP, FNLA – Part IV of V: statins, ezetimibe, PCSK9 inhibitors, niacin, cholesterol and the brain (10/18/2018)
#22 – Tom Dayspring, M.D., FACP, FNLA – Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteins (10/17/2018)
#21 – Tom Dayspring, M.D., FACP, FNLA – Part II of V: Lipid metrics, lipid measurements, and cholesterol regulation (10/16/2018)
#20 – Tom Dayspring, M.D., FACP, FNLA – Part I of V: an introduction to lipidology (10/15/2018)
#19 – Dave Feldman: stress testing the lipid energy model (10/8/2018)
#18 – Richard Isaacson, M.D.: Alzheimer’s prevention (10/1/2018)
#17 – Mike Trevino: life-lessons from ultra-endurance, mindset, hard work, and removing limitations (9/24/2018)
#16 – Formula 1 (with Paul Conti): the best drivers, Ayrton Senna, and the cautionary tales of driven individuals (9/20/2018)
#15 – Paul Conti, M.D.: trauma, suicide, community, and self-compassion (9/17/2018)
#14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system (9/10/2018)
#13 – Brett Kotlus, M.D.: How to look younger while we live longer (9/3/2018)
#12 – Corey McCarthy: Overcoming trauma, dealing with shame, finding meaning, changing the self-narrative, redemption, and the importance of gratitude (8/27/2018)
#11 – AMA #2: the Nothingburger — results from Peter’s week-long fast between two weeks of nutritional ketosis — and answering questions on all things fasting (8/23/2018)
#10 – Matt Kaeberlein, Ph.D.: rapamycin and dogs — man’s best friends? — living longer, healthier lives and turning back the clock on aging and age-related diseases (8/20/2018)
#09 – David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity? (8/13/2018)
#08 – Tom Bilyeu: nutrition, fasting, meditation, mindset, immortality, and the secret formula of fulfillment (8/2/2018)
#07 – Deep Dive: Lp(a) — what every doctor, and the 10-20% of the population at risk, needs to know (7/30/2018)
#06 – D.A. Wallach: music, medicine, longevity, and disruptive technologies (7/23/2018)
#05 – Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer (7/16/2018)
#04 – AMA #1: alcohol, best lab tests, wearables, finding the right doc, racing, and more (7/9/2018)
#03 – Ron Krauss, M.D.: a deep dive into heart disease (7/2/2018)
#02 – Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and more (7/2/2018)
#01 – Tim Ferriss: depression, psychedelics, and emotional resilience (7/2/2018)
